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Procedures for estimating mass loss expressed through lateral changes in groundwater geochemistry are specified in existing guidance documents [(ITRC 2009b)

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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2